Check out NetVibes.com
It has been out since September, but I only recently started really looking at it. My problem has been that I don’t need yet another page to load for my content. I rely on Firefox to manage my stuff for me. It is more private, secure, and available. If I wanted my information to be more web based then I would consider something like this, but I don’t even use my Google Homepage.
Netvibes uses AJAX (Asynchronous JavaScript and XML) to do some great things. It allows you to move boxes around easily by drag and drop, like Google and Start.com do, but it also links directly into some great “Web 2.0” tools like Writely and Flickr.
It has bookmarks, del.icio.us, a GMail module, any RSS feed you want or even Weather.com.
It supports IE 6 on Windows (but not well on Mac apparently), Mozilla, Firefox, and recently Opera. Safari (and I would assume Konqueror) are not yet supported as well as Lynx (I confidently assume). You can see more at the NetVibes Blog.
But, beyond that stuff, I really want to learn AJAX now.
Netvibes came out top in this review http://digg.com/links/Personalised_AJAX_Homepages:_Roundup_and_Review